INTRODUCTION: Mechanical thrombectomy (MT) is recommended treatment for acute ischemic stroke patients due to large vessel occlusions.Despite successful recanalization, patients may not have a good clinical outcome.This study aims to identify the predictors of good clinical outcome in acute stroke patients treated with MT.METHODS: This study was designed retrospectively.Acute ischemic stroke patients treated with mechanical thrombectomy because of the internal carotid artery or M1 segment of the middle cerebral artery occlusion between 2018 and 2022 were included in this study.mRS score ≤2 on the 90th day was defined as a good clinical outcome.RESULTS: A total of 110 patients were treated with MT.Good clinical outcomes occurred in 56 (50.9%) of patients.Good clinical outcome group had decreased levels of age (p<0.000),glucose (p=0.018),neutrophil-lymphocyte ratio (NLR) (p=0.010),C-reactive peptide (CRP) (p=0.004) and diastolic blood pressure (DBP) (p=0.009).The poor clinical outcome group had increased NIHHS scores at onset (p<0.001) and 24th hour (p<0.001).The good clinical outcome had higher rates of good collaterals (p<0.001) and successful recanalization (p<0.001).The rate of intracerebral hemorrhage was significantly low in the good clinical outcome group (p=0.007).DISCUSSION AND CONCLUSION: Good collaterals and successful recanalization are predictors of good clinical outcomes.ICH is a predictor factor of poor clinical outcomes.Younger age, decreased glucose, NLR, CRP, NIHSS score at onset and 24th hour, DBP, and procedure time are other predictors of good clinical outcome.