Monoclonal B-Cell Lymphocytosis (MBL) is part of the mature B-cell neoplasms despite actually being a pre-neoplastic condition [1], this entity, largely unstudied, affects more than 5-10% of older adults age 40 and the incidence increases with aging [2,3], MBL is widely associated as one of the main risk factors for developing Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL), since studies Prospective cohort studies verified, in effect, that CLL is always preceded by MBL, therefore, the greater the number of clonal B cells, the greater the risk of developing this type of cancer [4].