Although there are many investigations on the problem of vehicle routing, few consider the real slope changes in the road networks of cities. The objective of this work is to calculate the effect that the slopes of a road network can have on fuel consumption, combining a metaheuristic solution algorithm, traffic characterization and an algorithm for the calculation of road slopes. The results of the model show that considering the slope in the urban merchandise distribution model can increase the estimates of fuel consumption by 28.67%.