Aims: Perform the synthesis of novel fluoro phenyl triazoles via click chemistry with or without microwave irradiation and their evaluation as anti-proliferative agents in SiHa cells Background: Triazoles are heterocyclic compounds containing a five-member ring with two carbon and three nitrogen atoms. They are of great importance since many of them have shown to have biological activity as antifungal, antiviral, antibacterial, anti-HIV, anti-tuberculosis, vas-odilator, and anticancer agents. Objective: Synthesize novel fluoro phenyl triazoles via click chemistry and evaluate their anti-proliferative activity Methods: First, several fluorophenyl azides were prepared. Reacting these aryl azides with phe-nylacetylene in the presence of Cu(I) catalyst, the corresponding fluoro phenyl triazoles were ob-tained by two methodologies, stirring at room temperature and under microwave irradiation at 40 ºC. In addition, their antiproliferative activity was evaluated in cervical cancer SiHa cells Results: Fluoro phenyl triazoles were obtained within minutes by means of microwave irradia-tion. The compound 3f, containing two fluorine atoms next to the carbon connected to the tria-zole ring, was the most potent among the fluoro phenyl triazoles tested in this study. Interesting-ly, the addition of a fluorine atom to the phenyl triazole structure in a specific site increases its antiproliferative effect as compared to parent phenyl triazole 3a without a fluorine atom. Conclusion: Several fluoro phenyl triazoles were obtained by reacting fluoro phenyl azides with phenylacetylene in the presence of copper sulphate, sodium ascorbate and phenanthroline. Prepa-ration of these triazoles with MW irradiation represents a better methodology since they are ob-tained within minutes and higher yields of cleaner compounds are obtained. In terms of biological studies, the proximity between fluorine atom and triazole ring increases its biological activity.