Background: Surgical site infections are one of the most common complications in aesthetic surgery. Research is limited in Plastic Surgery, with reported rates of 05 to 32.6%. Although its overall incidence among most aesthetic surgeries is low, it carries a significant burden of morbidity, hospital readmissions, and prolonged hospital stay. Purpose: Our study aims to provide evidence-based recommendations regarding Prophylactic Antibiotic prescription during most common aesthetic plastic surgery procedures, based on what current tendencies are among plastic surgeons. Methods: We carried out an online anonymous-answer survey among different platforms from which board-certified Plastic Surgeon were active users/members. It was activated between February-April 2022 and available in three different languages: English, Portuguese, and Spanish. Questionnaire included a list of commonly performed aesthetic procedures and evaluated use/not use of antibiotic prophylaxis, duration of treatment, and type of antibiotic. Results: We got information from 2216 procedures in plastic surgery. 277 respondents answered each of 3 questions per procedure (n=8). Most commonly prescribed antibiotics were cephalosporins (73.3% of the surveys), followed by quinolones (12.9%). Duration of antibiotic therapy was most frequent in the group above five days (39,6%), followed by only five days (32,3%), while single doses were reported only in 12% of the cases. Conclusion: Emergence of multidrug-resistant microorganisms are a worldwide growing concern. Despite medical evidence and guidelines regarding antibiotic prophylaxis, surgeons keep misusing antibiotics. Our findings support the absolute need of active vigilance on antimicrobial prescription and its use in those cases with a clear indication for treatment.Funding: The authors received no financial support for the research, authorship, and publication of this article.Declaration of Interest: The authors did not have financial interest nor receive any financial support of the products or devices mentioned in this article. All other authors declare that they have no conflicts of interest.Ethical Approval: We strictly followed content policies from online surveys regarding personal information and/or location information. Surveys did not request information that we could use or recognize as personally identifiable information from end users neither from patients, including names, phone numbers and email addresses, social media accounts, employer, account credentials, government identification numbers, cardholder data and financial account data. Surveys did not include any information about personal medical records, nor data that could be used to identify them.