The last few years have been significant for "the creation of new companies carried out by researchers that have as a mechanism to generate value through scientific research known as university spin-off" (Castillo-Vergara & Alvarez-Marin, 2015, p. 2).According to Law 1838 of 2017: "A spin-off is understood as a company based on knowledge, especially that protected by intellectual property rights, generated within the scope of HEIs, resulting from research and development activities carried out under their support, in their laboratories and facilities or by researchers linked to them, among other forms" (p. 1).In order to approach the chapter, a documentary analysis was made that is related to the entrepreneur, his profile, his characteristics, motivation and emotional intelligence, previous aspects that must be recognized at the moment of wishing to work by his own means.The chapter takes into account the topic of spinoffs that arise as entrepreneurship and become knowledge transfer systems, as well as business development.(Bravo et al., 2019).