Introduction: This study provides scientific and theoretical principles for the formation of types of buildings and complexes based on programs of mixed functional (hybrid) use. Materials and Methods: The method of scientific and predictive classification of the design principles of multifunctional buildings and complexes of mixed hybrid structure is used. Results and Discussion: The article provides an analysis of practical examples of multifunctional and mixed urban development that form new architectural and spatial solutions for building types that change the situation in existing neighborhoods, streets, and public spaces. Conclusions: The factors of updating the typology of multifunctional buildings and complexes using the principles of hybridity, digital and information technologies are considered.