During field surveys conducted in 2021 in the Middle Magdalena River Valley, Colombia, we recorded a new dietary item for the snake Epicrates maurus, consisting of the rodent species Zygodontomys brevicauda. When photographed, the snake regurgitated the partially digested mouse, which was identified from its dental and cranial characters. The present record contributes to the knowledge about the dietary spectrum of E. maurus in northern South America.