Methanolic extracts were prepared from aerial biomass of wild populations of Passiflora coriacea, P. capsularis, P. magdalenae, P. smithii, P. vitifolia, and P. pittieri and evaluated for total phenols, tannins, and flavonoids. The qualitative and quantitative profiles of the extracts were established by UHPLC-ESI/MSMS, and their capacity to quench DPPH∙ and ABTS∙+ radicals was determined. There were positive correlations between the phenolic content and antioxidant capacity for all species analyzed, highlighting to P. vitifolia and P. pittieri which exhibited the highest values for all the determined parameters. Passiflora species from the Colombian Andean, may be a potential source of bioactive metabolites.