Chronic granulomatous colitis secondary to tuberculosis is an unusual manifestation of extrapulmonary tuberculosis, this pathological entity is difficult to diagnose because most of its symptoms are nonspecific, resulting in a late diagnosis and treatment, considering that the disease is curable and preventable.Case: 42-year-old man with abdominal pain of intensity 6/10.Physical examination revealed superficial and deep palpation pain in the right iliac fossa, without signs of peritoneal irritation.Paraclinical tests showed no signs of local or disseminated infection, but the histopathological study reported chronic colitis due to mycobacterium tuberculosis.Discussion: intestinal tuberculosis is the sixth cause of extra pulmonary infection, located in most opportunities in the ileocecal region, the clinical manifestations are fever, fatigue, weight loss and abdominal pain, management is done with antituberculosis drugs for an average period of 6 months, with subsequent clinical improvement and endoscopic remission.