Erythrasma and lichen sclerosus are usually found as separate entities, however it is rare for the two diseases to coexist in a patient in the same affected area.Next, we present the case of an adult, Afro-Colombian, and obese patient with a primary diagnosis of lichen sclerosus on the vulva, which is refractory to treatment with potent topical glucocorticoids secondary to the association with erythrasma in the same area.Summary: Erythrasma and lichen sclerosus are usually found as separate entities, however it is rare for the two diseases to coexist in a patient in the same affected area.Next, we present the case of an adult, Afro-Colombian, and obese patient with a primary diagnosis of lichen sclerosus on the vulva, which is refractory to treatment with potent topical glucocorticoids secondary to the association with erythrasma in the same area.