Objective:The objective of this study was to determine the prevalence and cardiovascular risk factors in patients with acute myocardial infarction (AMI) with non-obstructive coronary lesions on coronary arteriography in a health institution with intermediate and specialized care in the city of Valledupar (Cesar), Colombia.Materials and methods: This was a descriptive, cross-sectional, and single-center study.All patients included were over 18 years of age.They presented an acute coronary syndrome and were treated in a health center in Valledupar, Colombia.Coronary arteriography was completed, and patients met the criteria for myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the fourth universal definition of myocardial infarction.The prevalence of MINOCA and description by sex, age, cardiovascular risk factors, and type of acute coronary syndrome (ACS) presentation was calculated.The study was carried out between January 2016 and December 2019.Results: Of the 3,022 patients diagnosed with AMI, 215 did not have non-obstructive coronary lesions, with a prevalence of 7.11% (95% CI: 6.20-8.03%).Most subjects were women (53.02%), and the mean age was 56.6 years.Altogether, 75.8% of the participants had at least one cardiovascular risk factor, predominantly arterial hypertension (67.4%).Most patients had non-ST-segment elevation ACS (93.5%).Conclusion: The prevalence of MINOCA in our institution is within the range described in the medical literature.The clinical characteristics found were similar to those reported in the literature.Further studies need to be conducted to determine the cause in this type of patient.