Although researchers have widely studied the analysis and modelling of error sources on Global Navigation Satellite Systems positioning, some of these errors have not been eliminated significantly and only some of the Global Navigation Satellite System’s data are modelled. The present work was undertaken to determine the effect of different variables, namely: season, the number of visible satellites, and dilution of precision on the efficiency of horizontal and vertical CORS (Continuously Operating Reference Stations) positioning. For this aim, the CORS data was collected at 14 different test points during 600 epochs with 1-second intervals. Factorial designs supply an efficient solution to understand the impact of several factors on a response variable. A full factorial design with three factors at two levels was applied for these purposes. According to the results of the full factorial design, all factors significantly affected the response variable. Also, the interaction effects of factors were analysed on the CORS horizontal and vertical positioning. The regression equations were obtained for all situations.