Yam, inhame, or ñame, is one of the food crops with the greatest relevance for the population of different developing countries in Africa, Asia, America, and the Caribbean.Specifically, this crop includes several species of Dioscorea genus, which have been recently studied from a metabolic point of view to deal in depth with an understudied and undervalued crop such as yam.Likewise, it has been sought to carry out a much more accurate characterization of yam plants, to facilitate the approach of breeding processes, natural exploitation, and bioprospecting through the metabolic understanding of this crop.Thus, in this review, we sought to collect and present the most relevant information concerning the determination of the metabolic profile of yam.For this, the qualitative description of the yam plant metabolome was initially addressed, highlighting the dependence of the detected metabolites according to the tissue and plant species.This fact has allowed making key differentiation at the metabolic level between Dioscorea species.Subsequently, a quantitative description of the metabolic profile of yam was presented, mainly of its tubers, including carbohydrates, proteins, amino acids, lipids, vitamins, minerals, and other important secondary metabolites, such as steroidal saponins.From this, it was possible to appreciate in a general way the metabolic behavior of yams and identify aspects of relevance for yam cultivation that have not yet been exploited.