Adolescents exhibit great sensitivity to nicotine and social interaction; accordingly, it has been demonstrated that when both stimuli are presented together, they interact to enhance the incentive value of the context in which they occur. Noteworthy, most studies assessing the interaction between nicotine and social reward have used isolated-reared rats. Isolation during adolescence is an adverse condition that impacts brain development and behavior, so is not known if the interaction also occurs in rats without social deprivation. The present study used a conditioned place preference model (CPP) to examine the interaction between nicotine and social reward in group-reared rats. Adolescent Wistar rats were randomly assigned to four groups: vehicle (VEH), vehicle and a social partner (VEH-SOC), nicotine (NIC), and nicotine and a social partner (NIC-SOC). Conditioning trials occurred on eight consecutive days followed by a test session in which the preference change was assessed. Besides the establishment of CPP, we examined the effects of nicotine on (1) social behaviors during CPP trials and (2) tyrosine hydroxylase (TH) and oxytocin (OX) as markers of changes in the neuronal mechanisms for reward and social affiliation. Similar to previous results, adolescent rats showed enhanced CPP when nicotine and social interaction were presented together. This finding coincided with an increase in TH levels observed after nicotine administration only in socially conditioned rats. The interaction between nicotine and social interaction did not seem to depend on the effects of nicotine on social behaviors, since nicotine did not affect social investigation and decreased social play.