Background: Currently, HIV infection is considered a pandemic.Acute HIV infection can present with dermatologic manifestations.In some cases, the skin is often the first and only organ affected during most of the course of HIV disease.Antiretrovirals are drugs that are used to treat HIV/AIDS infections. Methodology:A systematic review was carried out through various databases from January 2013 to September 2022; The search and selection of articles was carried out in indexed journals in English and Spanish.Results: Skin disorders during HIV infection are numerous.Depending on the CD4 count we find manifestations such as xerosis, onychomycosis, oral candidiasis, seborrheic dermatitis, Kaposi's sarcoma, among other dermatological manifestations.Although many dermatological manifestations are associated with the CD4 lymphocyte count, it may not be present in the same way in all patients.Therefore, it is very hasty to affirm or classify the dermatological manifestations according to this CD4 count. Conclusion:This review offers up-to-date and detailed information on the main dermatological manifestations in both children and adults in HIV-positive patients, as well as the main manifestations depending on the CD4 count range.