Manihot esculenta, commonly known as cassava, manioc, or yuca, is one of the largest crops around the world, mainly in tropical and subtropical areas.Its important adaptive characteristics and low requirements for its growth, in addition to its nutritional value, have allowed the growth of its productive and economic development since the middle of the last century.Over time, key agronomic aspects have been established for adequate cultivation of cassava that allows for obtaining high yields and good productivity.Thus, in this review, it was sought to expose and discuss concisely the most relevant agronomic aspects concerning cassava cultivation.Initially, the morphological properties, growth stages, edaphoclimatic conditions, and varieties of cassava were exposed.Subsequently, the seeding process was described, including the selection of the seeds and the preparation of the soil.Also, aspects related to the care and nutrition of crops and soil conservation using fertilizers and the methodologies for pest and pest management were presented.Finally, manual and mechanized cassava harvesting methodologies were discussed, including their differences, advantages, and disadvantages.