Sweet potato crop is one of the most relevant root crops in the world, occupying the seventh position among the most important food crops.The nutritional and economic importance of this crop in low-income regions of different developing countries, in addition to its limited productive and application development, has drawn attention to a more in-depth study of sweet potato plants to establish ideas for the improvement of traits, productivity, and utility of the crop.In this sense, understanding the plant at a metabolic level and identifying the relationship between its metabolome and its phenotypic characteristics or growth properties are important aspects to study.For this reason, this review sought to collect and present the works carried out so far focused on the determination and study of the metabolic profiling of sweet potato plants.Initially, a qualitative description of the plant metabolome was made based on these works, highlighting the most relevant results.Subsequently, a quantitative description of primary metabolites, such as proteins, amino acids, lipids, and carbohydrates, was carried out, including a brief physicochemical characterization of sweet potato starch.Finally, vitamins, minerals, and other important secondary metabolites, such as flavonoids and anthocyanins, were described quantitatively.Through this, it was possible to make a global approach to the metabolic behavior of sweet potato plants and their phytochemicals with greater relevance, which provides nutritional and medicinal value.