Ever since the emergence of the COVID-19 outbreak, there have been so many casualties worldwide.According to WHO, more than half a billion people were infected by the virus, of which 6.5 million deaths were counted.However, some already existing antivirals were repositioned and repurposed as anti-COVID-19 therapeutics such as molnupiravir, favipiravir, and ritonavir.The emergency needs to develop effective anti-viral drugs for the treatment of COVID-19 infection Consequently, there arose a need for effective, rapid, accurate, and reliable techniques for the determination of these antivirals.Here in this review, the different reported analytical methods for the quantitative determination of the studied anti-viral drugs were discussed.These reported methods include spectrophotometric methods, spectroflurometric methods, electrochemical methods, and different chromatographic methods, wither the reported method used for the quantitative determination of the studied anti-viral drugs in a single dosage form or in a co-formulated mixture also in different biological fluids and samples.