Objective: to analyze interculturality in the daily implementation of the integral health care model in Guainía, Colombia, under the critical lens of decolonial thinking.Methodology: Holistic single case study with the voluntary participation of 22 indigenous users, 26 health professionals and 3 key participants (a traditional doctor, an administrative official and an indigenous leader).The study settings were the hospital, health posts and health centers belonging to the public health care network.Data were collected through semi-structured interviews and direct observation.The analysis was guided by Bardin's thematic content analysis technique.Results: interculturality has been configured in the daily implementation of the health care model ANTROPOLOGÍA in Guainía, according to three different perspectives: relational, functional and critical.Conclusions: it is evident that interculturality can acquire different meanings in the field of health care in culturally diverse territories, being fundamental to promote a critical perspective based on the daily actions and the agency of the people, as well as working together with the communities to identify needs, limitations and potentialities, which allow the scope and concretization of a true dialogue of knowledge.