ABSTRACTABSTRACTThis study presents solubility determination and the thermodynamic analysis of celecoxib (CXB) in two kinds of solvent mixtures of N-methyl-2-pyrrolidone (NMP) + ethanol and NMP + 1-propanol at various temperatures (293.15–313.15 K). The density of CXB-free mixtures of NMP + 1-propanol at various temperatures was also measured since the data was not available from the literature. In both systems, the solubility raised with temperature and increased with increasing the amount of NMP in the blends. Measured solubility data were fitted using four mathematical cosolvency models. The resulting MRD% values for all examined models were less than 6.0. The measured densities of the CXB saturated solutions were calculated using an adopted version of Jouyban-Acree model. Further, predictive versions of the model which were trained using the density of drug-free mixed solvents were also used to predict the density of CXB saturated solutions with an overall MRD% of 1.3.KEYWORDS: DensityJouyban-Acree modelJouyban-Acree-van’t Hoff modelsolubilityvan’t Hoff model AcknowledgementsThis work was supported by Research Affairs of Tabriz University of Medical Sciences (Tabriz, Iran) under grant number 69537.Disclosure statementThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/00319104.2022.2163635Additional informationFundingThis work was supported by the Tabriz University of Medical Sciences [69537].