Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, an infectious disease caused by the Leishmania parasite and transmitted by phlebotomine sandflies. CL is manifested as skin lesions, which typically evolve to ulcerative lesions and may last for months or even years, if not treated. Currently available treatments against CL involve the use of particularly toxic and overpriced drugs, which, among other things, require long times of administration and do not always lead to the complete recovery of the patient. The use of in silico technologies, as the Universal Immune System Simulator (UISS), may be helpful in finding new and potentially more effective drugs against CL.