This study aimed to investigate the cerebral volumetric changes measurable by brain magnetic resonance imaging, as well as the different physiological variables documented through neurobiofeedback equipment, before and after 30 serial sessions of guided meditations in a sensory isolation tank. A pilot test was carried out, with a single subject, and it was concluded that serial sessions of meditations in flotation tanks changed the brain structure, triggered the relaxation response, generating greater physical, psychological and mental well-being for the research participant.