This paper presents an exploratory, descriptive study with a non-experimental design that addresses resilience in nursing staff working in a public hospital in Northern Mexico. The aim of this research was to identify if there were significant differences between the levels of resilience and demographic variables in the nurses. The sample size was n = 237 nurses. To collect data, we used the CD-RISK-25 (Connor-Davidson Resilience Scale, 2003). We used a crosssectional, exploratory and descriptive study with a non-experimental design. The global rating of the questionnaire had a Cronbach’s alpha of 0.871. The main results showed that 89.5% of the respondents had a high level of resilience; women had higher resilience than men and so do employees older than 46 years old, staff with a seniority of 10 years, head nurses and pediatrics staff. These findings have practical implications and important theoretical contribution for nurses and health staff that is continually struggling with secondary trauma and patient suffering.