Chronic Obstructive Pulmonary Disease (COPD) is currently the fourth leading cause of death in the world, but is projected to be the 3er leading cause of death by 2020. Additionally, 80% of patients with COPD have periodic exacerbations of their symptoms that tend to increase progressively in frequency and intensity, constituting one of the factors that determines the poor quality of life of these patients and a frequent cause of death. We sought to determine the factors associated with COPD exacerbations in the emergency services of 8 basic level hospitals in the Colombian coffee zone. A Prospective correlational study was carried out, taking as a population the patients that go to the emergency department of 8 basic level hospitals diagnosed with COPD and classified according to the GOLD guidelines (mMRC and FEV1). Descriptive demographic variables were recorded and we sought to identify the factors associated with their exacerbation. The study was developed in 2019. 356 patients were admitted to the study of which 64 were excluded in view of not having complete data. The average age was 70 years (SD 16.5), the majority were male (58.54%) of low education (87.8%). The most frequent GOLD stadium was D (47.23%). The main factor associated with emergency consultation was having had other previous exacerbations in the last year. The majority of patients present more than 2 exacerbations per year with 51.22% (p< 0.08), increasing the susceptibility to acquire respiratory infections, which are presented in 41.46% (p<0.1), also noncompliance with their oxygen therapy and exposure to environmental toxins, were factors that were related to exacerbations, but they had no statistical significance.