Throughout history, some plants have been taken as a medicinal alternative, which has been little studied. Their phytochemical compounds have been used for many years by our ancestors, demonstrating that they have components capable of saving lives. Heliotropium indicum is quite common in tropical and subtropical countries, it has been reported as a common field weed, but its main components, the pyrrolizidine alkaloids, have a pharmacological potential for different pathologies or pathological processes. So much so that its main alkaloid, Indicine N-oxide has been evaluated in vivo in cancer patients, although it has also been shown to be a hepatotoxic compound. All parts of the plant have important compounds for pharmacological study and identification, individualizing each component and reviewing its potential is important for further study to better understand the plant. All parts of the plant have compounds important for pharmacological study and identification, individualizing each component and reviewing its potential is important for further study to better understand the plant. This review allows to have a potential vision for its use of the different compounds and their effect on humans for a massive use, in addition to analyze the phytochemical uses of Heliotropium indicum and its uses in traditional medicine and its possible arrival in modern medicine as an alternative to treatments currently used.