Some research has highlighted the interrelationship between Quality Management and Knowledge Management for designing methods that help to achieve organizational excellence.Since the adaptability to changes determines the process competitiveness, it is necessary to unify the production of knowledge with 4.0 technologies, resulting in the smart industries.The objective of this paper is to develop a framework to jointly manage aspects of quality management and knowledge management, understanding their interdependence and joint contribution to organizational success.Therefore, we propose a new model for integrating Knowledge Management System and Quality Management System in Industry 4.0, based on a documentary, descriptive and quantitative data analysis carried out through surveys to a population interested in the subject.The proposed model is a response to the business need for tools that facilitate management in the context of Industry 4.0.It allows to focus on the most important variables of quality management and knowledge management and can be applied in any type of organization that has implemented 4.0 technologies.