New coordination complexes were synthesized from triamterene with Zn(II) and Mn(II) salts. The complexes formed were characterized by thermogravimetry, spectroscopy, morphology and dissolution rate studies. N5 was identified as a coordination site with the metals, changing the crystallization properties of the TAT ligand and altering its stability. A change in morphology and decrease in crystal size is associated with an increase in the dilution rate of the new materials, which diluted 40% faster in distilled water than TAT. The obtained compounds were subjected to biological studies, in a dose range between 0.5 µg/mL and 8 µg/mL. The cyto-genotoxic results showed that the cell cycle of the MCF-7 cancer cell line was affected, decreasing its mitotic index to values below 1%. The hemolysis and photo-hemolysis tests guarantee that the same doses of TAT can be maintained for the complexes, since there is no hemolytic activity. The antibacterial activity test showed that there is no antimicrobial potential by any of the compounds.