<b>Objective:</b> to describe in a cohort of patients from a tobacco cessation program how many presented COVID-19 and required hospitalization, and to evaluate differences between patients with active smoking and ex-smokers. <b>Material and methods:</b> 246 patients from the Fundación Neumologica Colombiana (EXFUMAIRE) smoking cessation program since 2015 were included. Two telephone contacts were made in 12 months to complete a 10 question questionnaire on respiratory and non-respiratory symptoms, diagnosis of SARS CoV-2 infection, smoking status, treatment received and complications. <b>Results:</b> 238 patients (96.7%) answered at least one call. The average age was 59 years, 49% women and with an IPA of 23.8. The most frequent comorbidities were respiratory (46%), cardiovascular (25.6%) and metabolic (2.8%). The cessation rate at 12 months was 62.2%. Of the total, 17 patients (7.7%) had COVID-19, one required hospitalization (5.9%). and reinfection was documented in one. There were no complications or deaths associated with COVID-19. There were 60 patients (25.2%) who underwent at least one screening test for any reason. Cardiovascular comorbidities were higher in patients without COVID-19 (p=0.008). There were no differences between groups with and without COVID in age, sex, other comorbidities, degree of smoking, smoking status, dependency, or motivation. <b>Conclusions:</b> A high telephone response was obtained from the participants (96.3%). The cessation rate at 12 months was 62.2%, the percentage of diagnosis of COVID-19 was low (7.7%), the same as the hospitalization rate in infected patients, and there was no associated mortality. There were no differences with respect to smoking status.
