The pandemic has predisposed all healthcare professionals to assess all viral pneumonia cases preliminarily as COVID-19, with a definitive diagnosis of COVID-19 made on the basis of a positive RT-PCR result.Occasionally, however, there are cases with negative RT-PCR test results both with thoracic CT findings indicative of COVID-19.It is thus very important to consider immunosuppressive conditions and other viral types of pneumonia in the differential diagnosis in patients who do not seem to respond to COVID-19 treatments.We present her a case of HIV infection identified in a differential diagnosis of ground glass opacities.