The effects on the quantity and quality of water is a problem of more attention in the world since anthropogenic activities have effects either by catchments or discharges. In the present work, an evaluation of the impact of anthropogenic activities in the Rancheria River basin (Guajira, Colombia) was carried out based on the collection of hydro-climatological information and quality of the water resource, added to the implementation of modeling. The results showed how there is pressure on the Rancheria River both due to this (collections) as well as due to the different discharges (domestic and non-domestic) that lead to water vulnerability or poor water quality in areas of the basin. Additionally, the climate change scenarios showed how in the future the situation could worsen for the communities if decisions are not made, since there will be years of flooding as well as deterioration in the quality of the water resource due to the presence of metals such as lead.