<title>Abstract</title> Erectile dysfunction (ED) is one of the most common complaints about male sexual health. Nesfatin-1 regulates food intake and has many functions in the body. We aimed to determine whether nesfatin-1 is involved in the etiology of ED. Forty-three men with ED (group 1) and 40 healthy men (group 2) were included in the study. The participants were evaluated by the Turkish version of the IIEF-5 (International Index of Erectile Function). Nesfatin-1, total testosterone, fasting blood glucose, hemoglobin A1c, total cholesterol, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, triglyceride and total prostate specific antigen (> 45 age) tests were performed on all cases. The mean ages were 47.47 ± 11.19 and 46.03 ± 8.30 (Mean ± Standard deviation) years in groups 1 and 2, respectively. The average IIEF-5 score were 13.14 ± 5.03 and 23.65 ± 1.17 in groups 1 and 2, respectively. Serum Nesfatin-1 levels were 14.521 ± 17.30 ng/ml in group 1 and 22.675 ± 21.03 ng/ml in group 2. A statistically significant difference was found between the groups’ serum nesfatin-1 levels, total cholesterol, LDL, and HDL (p < 0.05). No correlation was found between serum nesfatin-1 levels and the severity of ED. Nesfatin-1 may be involved in erectile physiology. Low serum Nesfatin-1 level may be among the etiological causes of ED.
