This Special Issue has focused on the subject of the development of graduation skills in computer professionals applied in the 5.0 society in the Ibero-American region, mainly considering the work in Projects of multidisciplinary and transdisciplinary training in the teaching processes of engineers and application of new technologies in Society 5.0. The Special Issue includes eight articles that cover a wide range of topics of this area, including graduate skills in Society 5.0, evaluation of the graduate skills of engineers, curricular innovations in the training of engineers for Society 5.0, new paradigms in the teaching of engineering toward Society 5.0, and application of new technologies in Society 5.0.