highlight health inequalities of homeless adolescents based on the conceptual framework of social determinants of health.this is a convergent parallel mixed-methods study. The population consisted of adolescents who are homeless, with purposeful sampling and data saturation. Quantitative data were obtained with a questionnaire and qualitative data through semi-structured interviews.19 homeless adolescents participated in the study, 13 (68.4%) aged 16 to 19 years; 11 (57.9%) were male, 3 (15.8%) were female, and 5 (26.3%) were transgender adolescents. Participants experienced different levels of exposure and vulnerabilities to conditions that affect health and were directly related to intermediate determinants of health.this study provides an understanding of the inequalities related to the health of homeless adolescents and shows evidence that supports strategies to promote equity and dignity in health care.(1) Contribute with strategies towards equal access to health services and dignity in adolescent care. (2) Understand the health needs of homeless adolescents. (3) Reflect on adolescent health care. (4) Support the health system and reduce health inequities.