To describe the relevant findings in the diagnosis of cervical ectopic pregnancy CEP and interstitial ectopic pregnancy IEP in order to focus their management. This observational study included patients diagnosed with ectopic pregnancy between January 2019 and February 2022 at the Fundacion Santa Fe de Bogotá University Hospital. Paraclinical and ultrasonographic variables were evaluated. A descriptive analysis of the patients. To be selected, cases of PSC and IEP had to meet the ultrasonographic criteria of the Society of Obstetricians and Gynecologists of Canada, SCOGC, and cases of IEP had to meet the Timor-Tritsch criteria. The management established for each case and the prognostic factors for the success of pharmacological and/or surgical treatment were then discussed. Of 502 medical attendances for bleeding and pain in the first trimester of pregnancy, 102 were diagnosed as ectopic pregnancies, of which 3 cases of CEP and 2 cases of IEP were selected. Of the 2 IEP cases: BhCG level of 4670 and 2016 mIU/mL, both had a vascularised gestational sac (GS) without embryo, gestational age less than 6 weeks and were treated with multiple doses of Methotrexate (MTX) 1mg/kg, neither required surgical treatment. Of the 3 cases CEP BhCG level of 37174, 4770, 865 mIU/mL, all 3 had a vascularised gestational sac (GS), gestational age less than 9 weeks, no embryo and were treated with multiple doses of Methotrexate (MTX) 1mg/kg, two required surgical treatment and one was additionally treated with intrasaccular methotrexate. Multi-dose and intrasaccular MTX management of CEP and IEP reduced the need for QM. Determining factors for treatment success were BHGC levels at diagnosis, presence or absence of embryo, and gestational age.