Sepsis is a serious clinical picture characterized by damage to the immune system as a result of the body's uncontrolled response to infection. In sepsis, there is a systemic inflammatory response to infection from various pathogens. In this context, the mechanism of inflammatory mediators such as cytokines and chemokines in sepsis may be important in the treatment. We aimed to determine whether resveratrol has positive effects in the experimental sepsis model created with Lipopolysaccharide (LPS).For the study, 28 male Spraque Dawley rats were randomly divided into four groups (n=7). The Control group, LPS group (30 mg/kg dose), resveratrol group, and the group were given resveratrol together with LPS. After the completion of the experimental protocol, liver and kidney tissues were collected, and in addition to histopathological evaluation, malondialdehyde (MDA) level, which is an oxidative stress marker, and immunoreactivity of Toll-like receptor-4 (TLR4), tumor necrosis factor- (TNF-α), transcription factor NF-κB evaluated immunohistochemically. In addition, expression levels for TLR4, TNF-α, NF-kB, Interleukin 1 beta (IL-1β), and Interleukin 6 (IL-6) were measured. In addition, AgNOR staining was performed in liver and kidney tissue.When the results were evaluated, LPS application caused severe tissue damage and oxidative stress and increased the expressions of the proteins we evaluated (TLR4 / NF-kB / TNF-α), while resveratrol application eliminated these negativities.