PURPOSE: The aim of this study was to determine the relationship between socio-demographic correlates and Human Development Index (HDI) with accelerometer-measured physical activity intensity in a multicenter study. METHODS: We based our analyses on the Latin American Study of Nutrition and Health adult study (ELANS), which was a coordinated, international, cross-sectional study. 2522 adults aged 18-65 (mean 38.6) years from eight Latin America countries (i.e., Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela) were considered. Accelerometer-measured sedentary time, physical activity intensity (light and moderate-to-vigorous) and steps per week. Sex, age, and ethnicity were assessed as socio-demographic correlates. The HDI country information was obtained from the United Nations Development Program. Linear regression models reporting unstandardized beta coefficients and 95% confidence intervals were used. RESULTS: Participating countries were classified as high (Brazil, Colombia, Ecuador, Peru, and Venezuela, n = 1.730) and very high (Argentina, Chile, and Costa Rica, n = 792). Women had lower levels of sedentary time (β: -18.53; 95%CI: -28.16, -8.89), moderate (β: -12.62; 95%CI: -14.52, -10.73), vigorous (β: -0.74; 95%CI: -0.94, -0.54), moderate-to-vigorous physical activity (β: -13.36; 95%CI: -15.32, -11.41), and steps per week (β: -1266.48; 95%CI: -1667.83, -865.14) than men. Younger adults presented lower sedentary time (β: -0.69; 95%CI: -1.05, -0.33), moderate (β: -0.09; 95%CI: -0.17, -0.02), vigorous (β: -0.02; 95%CI: -0.03, -0.01), and moderate-to-vigorous physical activity (β: -0.11; 95%CI: -0.19, -0.04) than older adults. Mixed (β: -2853.90; 95%CI: -3703.13, -2004.68) and White/Caucasian (β: -2193.30; 95%CI: -3076.45, -1310.14) ethnicity had lower steps per week than Black ethnicity. Countries with very high HDI had higher levels of vigorous physical activity (β: 0.26; 95%CI: 0.03,0.49), but lower steps per week (-847.28; 95%CI: -1298.31, -396.26) than high HDI. CONCLUSIONS: We found relationship between socio-demographic correlates and HDI with sedentary time, physical activity intensity (mainly moderate-to-vigorous) and steps per week which can in turn guide policies to promote physical activity in the Latin America region.