<h3>Introduction</h3> Thromboembolic events are among the most critical complications in neuroendovascular procedures, and dual antiplatelet therapy (DAPT) can reduce them. The effects of using aspirin and clopidogrel in the DAPT are well characterized but using aspirin and ticagrelor has been less studied. <h3>Methodology</h3> A retrospective cohort study was conducted between April 1, 2015, and December 30,2020. The study included patients with endovascular treatment with diverting and non-flow diverting stents for unruptured cerebral aneurysms who received DAPT with aspirin and clopidogrel or with aspirin and ticagrelor. <h3>Results</h3> One hundred forty-eight patients with unruptured intracranial aneurysms with diverting and non-flow diverting stents started DAPT with aspirin (100mg/day) and clopidogrel (75mg/day). Twenty-four of these patients had a poor response to clopidogrel according to the VerifyNow® test and had their DAPT changed to aspirin(100mg/day) and ticagrelor (90 mg/every 12 hours). One thrombotic complication (0.81%) and one bleeding complication(0.81%) occurred in patients receiving DAPT with clopidogrel and aspirin during the procedure. None of these complications(0.00%) occurred in patients receiving DAPT with ticagrelor and aspirin. At the six-month follow-up, four patients(3.15%) in the clopidogrel group presented thrombotic complications and none(0.00%) in the ticagrelor group. Regarding the hemorrhagic complications, four patients(3.23%) in the clopidogrel group had these complications, and one(4.17%) in the ticagrelor group six months after the procedure. <h3>Conclusion</h3> DAPT with ticagrelor and aspirin is a safe and effective alternative to DAPT with clopidogrel and aspirin for patients with an inadequate response to clopidogrel. <h3>References</h3> Narata AP, Amelot A, Bibi R, <i>et al</i>. Dual Antiplatelet Therapy Combining Aspirin and Ticagrelor for Intracranial Stenting Procedures: A Retrospective Single Center Study of 154 Consecutive Patients with Unruptured Aneurysms. Neurosurgery [Internet]. 2019 Jan 1;<b>84</b>(1):77–83. Available from: https://Journals.Lww.Com/Neurosurgery/Citation/2019/01000/Dual_Antiplatelet_Therapy_Combining_Aspirin_And.10.Aspx Park KY, Ozaki T, Kostynskyy A, <i>et al</i>. Ticagrelor versus Clopidogrel in the Dual Antiplatelet Regimen for Intracranial Stenting or Flow-diverter Treatment for Unruptured Cerebral Aneurysms: A Single-center Cohort Study. <i>American Journal of Neuroradiology [Internet]</i> 2021 Sep 1;<b>42</b>(9):1638–44. Available from: http://www.Ajnr.Org/Content/42/9/1638 <h3></h3> <b>Do you have any conflict of interest to declare?</b>: No