cognitive and affective alterations, sleeping quality, and even neurodegenerative diseases, so the different factors that can affect this important and fragile system can be emphasized, as IntroductIonThe GS is a virtual perivascular network in the brain that has the function of transporting brain substances toward neurons and then toward the exterior of the brain, for neural metabolism and its residue, from the interstitium to the meningeal lymphatic vessel.This system of clearance of residues and the remaining neurotoxic increases its action in situations like the reduction of the state of consciousness, during sleeping, or under the effect of anesthetic agents. 1,2][5] The purpose of this bibliographic review is to mention some fundamental aspects associated with the physiology and physiopathology of the GS in relation to the neuroinflammatory response during traumatic brain injury, in addition to the negative effects that inadequate flow in the brain brings in the short-term, as well as in the long term, there can be 1,2