<h3></h3> Flow disruption technology using WEB device has been used safely for the treatment of wide-neck bifurcation aneurysms, but the use of this endosaccular approach to treat side-wall lesions in terms of feasibility, safety, stability and aneurysm occlusion rateafter this treatment is unknown. <h3>Materials and methods</h3> Patients were carefully selected. IRB approved. Procedure related complications, procedural time, antiplatelet therapy requirements. Web Occlusion Scale (WOS) was used for the Follow-up. <h3>Results</h3> From August 2017 and March 2021 a total of 14 wide-necked, sidewall, IA were selected for WEB treatment. Aneurysm mean size 5.3mm in width and 5.8 in height. Aneurysm Location: ICA 8 cases (five PComA, two Carotid-ophtalmic segment, one AChoA segment), Superior Cerebellar Artery SCA in 5 patients (35%), and one impressive case in posterior circulation associated with a basilar fenestration next to VBJ. Eight cases were unruptured (57%), and six cases with history of SAH- acute setting.DAPT used pre operatively in all elective cases but none patient remain under antiplatelets after procedure. Technical success of 100%.Mean procedure time: 24 min. None related procedure complications recorded. Immediately angiographic occlusion was evidenced in 9 cases. Radiological Follow up (ranging 1- 26 months) available in 9/14 showed a WOS adequate occlusion in all cases. <h3>Conclusion</h3> In our early experience using WEB device to treat different conditions than bifurcation IA´s, the results showed that endossacular approach was feasible in highly selected patients, safety profile in agreement with previous bifurcation experiences and very effective to treat challenge cases with a high probability of recurrence or therapeutic failure. <h3>References</h3> Heiferman DM, Goyal N, Inoa V, Nickele CM, Arthur AS. A New Era in the Treatment of Wide Necked Bifurcation Aneurysms: Intrasaccular Flow Disruption. <i>Interv Neuroradiol</i>. 2022 Apr 26:15910199221094390. DOI: 10.1177/15910199221094390. EPUB AHEAD of Print. PMID: 35469513. <h3></h3> <b>Do you have any conflict of interest to declare?</b>: No