The amputation of a limb is a disabling condition that affects millions of people worldwide.This situation bolsters the necessity of devices that help the integration of those individuals into society.However, the design of such mechanisms faces many issues for their simple implementation, such as the reduced space to add actuators while maintaining an aesthetical design.This situation increases the complexities of manufacturing high dexterity upper arm prostheses.Thus, a cable-driven wrist prosthesis (CDWP) is proposed to solve these issues.Besides, the Anti-Parallel-based local Transmission Index is presented as a performance index to optimize the device's dimensions.Ultimately, by applying the methodology proposed in this article, researchers would be able to dimension the proposed CDWP for a wide range of patients.