COVID-19 most commonly affects the respiratory system; however, in the past two years, we have seen it affects multiple organ systems, including neurological, and continue to learn its effects. This article presents a 69-year-old female with a history of cognitive impairment with hallucinations, treatment for syphilis, and twice vaccination for COVID-19, who presented to the emergency department (ED) with altered mental status. She later developed a subdural hemorrhage (SDH) after testing positive for COVID-19 during admission.