Introduction: In tarsal tunnel syndrome (TTS), the neural mobilization technique, one of the conservative treatment methods, aims to relieve abnormal nerve tension with appropriate movements of the nerve tissue. The aim of this study was to investigate the effect of tibial nerve mobilization in addition to home exercise on the tibial nerve area in patients diagnosed with TTS.Methods: The study included 40 participants, including 20 cases in the intervention group (IG) (mean age, 46.75±8.20 years) and 20 in the control group (CG) (mean age, 46.35±9.12 years) who met the inclusion criteria. IG received tibial nerve mobilization and a home exercise program for and foot-ankle joint. Participants in the control group had only a home exercise program for the foot-ankle joint. The patients were evaluated at baseline and at the end of 4th weeks.Results: After treatment, a significant difference was observed in favour of the post-treatment values in the intervention group for the post-treatment findings of Tinel's sign (p<0.01), whereas a statistically significant difference was not observed in the control group (p=0.70). Also, when the difference between the groups was examined, statistical significance was observed in favor of the intervention group (p = 0.02). Although the main time-related effects were statistically significant for tibial nerve area measurements (p=0.04), the difference between groups (p=0.87) and interaction effects was not significant (p=0.38).Conclusion: This study showed that the addition of tibial nerve mobilization to home exercise program can improve pain severity, functionality and Tinel's sign in patients with TTS.