Asia was reborn as a continent with great productive, commercial, and innovation capacities that have impacted the international system, thus challenging Colombian foreign policy. Over the last century, the accepted subordination to US global strategic design was the main characteristic of this country’s foreign policy. The objective of this article is to present the requirements that an assertive response implies in face of the Asian global challenge. In this regard, it is argued that, given the size and development conditions of Colombia, a policy towards Asia requires improving its negotiation capacity. This requires a robust Latin American regional integration program. In the domestic context, it is also essential to advance the democratization of the external agenda by enriching the deliberation process via the incorporation of new agents, beyond bureaucratic teams, and the business community.