Background: Ultrasound-Guided Transversus Abdominis Plane (USG-guided TAP) block is now utilized as an auxiliary analgesic to reduce the usage of opioids during surgery and to reduce the use of systemic analgesics for postoperative pain management.Objective: The aim of the current work was to compare USG-guided TAP block efficacy and patient-controlled analgesia in women undergo caesarean section.Patients and Methods: This study conducted on 60 pregnant women aged 19-40 years who were scheduled to undergo caesarean section under general anaesthesia, attended at Department of Obstetrics and Gynaecology, Faculty of Medicine, Menoufia University.Results: Both groups' VAS values declined considerably over time (p=0.05) in the within-group comparison.The SpO2 values did not show any significant difference between the study groups and in the within-group comparison.While, they were considerably higher in Group 1 patients at the postoperative 30 th minute and 1 st , 2 nd , 3 rd , 6 th , 12 th , and 24 th hours (p=0.003) in the between-groups comparison.In the between-groups comparison, there were no significant differences in VAS values.Nausea-vomiting were significantly increased among patients of group II (2.0 ±0.7) than group I (1.2±0.4) at 30 th minute (p=0.015).On contrast, Nausea-vomiting did not show any significant differences among group I and II after, 1, 2, 3, 6, 12 and 24 hours postoperatively.Conclusion: TAP block could be considered a more desirable approach than intravenous patient-controlled analgesia (PCA) since it avoids the systemic effects of morphine used in PCA and its analgesic impact begins sooner.