Background: Chronic obstructive pulmonary disease (COPD) is still defined as a disease state characterized by poorly reversible airflow limitation induced by cigarette smoke and/or other noxious particle and gases. The aim of this study was to evaluate the effect of intervention program for adults with chronic obstructive pulmonary disease on their knowledge and practices regarding compliance to self-care management. Research design: A Quasi-experimental research design was utilized to fulfill the aim of this study. Setting: This study was conducted at outpatient clinic of Menia Chest Hospital, Menia Governorate, Egypt. Sample: A purposeful sample of 115 COPD patients. Tool; one tool was used included six parts. (1 socio-demographic characteristics of COPD patients, (2 medical history of COPD patients (3 the effect of COPD on activity of daily living and health status of COPD patients (4 Patents’ knowledge about COPD, (5) adults 'compliance to self-care management and (6) adults reported practices regarding self-care management. Results: less than two third of the studied sample had unsatisfactory total knowledge of COPD, in pre intervention program, comparing to less than three quarter of them had satisfactory total knowledge regarding COPD in post intervention program.