Dissecting cellulitis of the scalp is a rare inflammatory disorder of unknown etiology. It is clinically characterized by the formation of painful suppurative chronic nodules and abscesses, which are connected by fistulae that, although they can be cured, as a consequence leave patients with irreversible alopecia. Currently, there are only a few cases reported in the literature. Here we present the case of a 45-year-old patient with dissecting cellulitis of the scalp, focusing on the histopathological findings and clinicopathologic correlation.