Objectives: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to insulin deficiency and/or resistance. Beyond coagulation, the health benefits of VK have been described to play different roles in both physiological and pathological processes such as inflammation, energy metabolism, neuroprotection, cellular growth and survival. It was aimed to observe the antioxan and/or neuroprotective activity of vitamin K3 in our model of chick embryo diabetic neuropathy (DN) induced by STZ.Methods: 90 White Leghorn, fertile and 0-day-old SPF (specific pathogen free) eggs (57±4 gr) were used in the study. Eggs were divided into 9 groups (control and drug groups). On the 12th day of incubation, 2 different doses of Streptozocin (STZ) (0.15 and 0.30 mg/egg) were administered into the air sac. 2 hours after STZ administration, 3 different doses of VK (0.05, 0.025 and 0.005 mg/egg) were administered and incubated. Plasma insulin and glucose levels were measured. In addition, brain tissue total antioxidant level (TAS), total oxidant level (TOS), malondialdehyde (MDA) and vascular endothelial growth factor (VEGF) levels were measured. Results: Plasma glucose levels were higher in the STZ-treated groups and lower in the treatment groups. Plasma insulin levels were observed to be higher in STZ groups in groups treated with high VK. Low TAS, high MDA, TOS and VEGF levels were recorded in brain tissue STZ groups. Low VEGF, TOS and MDA levels were recorded in the group treated with the highest VK, while high TAS levels were observed.Conclusions: In our STZ-induced chick embryo diabetic neuropathy model, we observed that VK3 reduced oxidant damage by showing antioxidant properties or by modulating antioxidant enzymes.