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Dynamics of a Mathematical Model of Cancer and Immunoediting Scenarios Under the Variation of the Immune Cell Activation Rate

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Abstract:

This article investigates the dynamics of cancer through a coupled system of three nonlinear ordinary differential equations. The evolution of the cancer tumour is examined under the variation of the immune cell activation parameter, and the study determines the values of this parameter that cause changes in the dynamics of this evolution; these changes are a consequence of two transcritical bifurcations and a supercritical Hopf bifurcation that exist in the system. These results reveal the range of immune cell activation for which tumour escape or tumour latency, or oscillatory behavior due to the appearance of limit cycles, is achieved. In addition, an optimal value is distinguished for which a minimum number of active immune response cells is sufficient to bring the tumour to a latent state.

Tópico:

Mathematical Biology Tumor Growth

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Citations: 1
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Información de la Fuente:

SCImago Journal & Country Rank
FuenteInternational Journal of Bifurcation and Chaos
Cuartil año de publicaciónNo disponible
Volumen32
Issue06
Páginas2230014 - N/A
pISSNNo disponible
ISSN0218-1274

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