Abstract Conventional, hadronic matter consists of baryons and mesons made of three quarks and a quark–antiquark pair, respectively 1,2 . Here, we report the observation of a hadronic state containing four quarks in the Large Hadron Collider beauty experiment. This so-called tetraquark contains two charm quarks, a $$\overline{{{{{u}}}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover> <mml:mrow> <mml:mi>u</mml:mi> </mml:mrow> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> and a $$\overline{{{{{d}}}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mover> <mml:mrow> <mml:mi>d</mml:mi> </mml:mrow> <mml:mo>¯</mml:mo> </mml:mover> </mml:math> quark. This exotic state has a mass of approximately 3,875 MeV and manifests as a narrow peak in the mass spectrum of D 0 D 0 π + mesons just below the D *+ D 0 mass threshold. The near-threshold mass together with the narrow width reveals the resonance nature of the state.